Email:  mbamman@uab.edu
  Telephone: 205.996.7937
  Fax: 205.996.9286
  Address:  MCLM 966-A
                1918 University Blvd
                Birmingham AL 35294-0001

Dr. Bamman graduated from Kansas State University in 1989 with a bachelor of science degree in exercise science. He then enrolled at UAB in Birmingham, Alabama where he completed a masters degree in exercise physiology in 1990. Dr. Bamman earned a doctorate in the Department of Physiology at the University of Florida in 1996. As a PhD candidate in late 1993, he traveled to the NASA Johnson Space Center in Houston, Texas where he conducted space flight-related research on skeletal muscle for nearly three years. Dr. Bamman joined the UAB faculty in 1996 with a primary appointment in the Department of Physiology and Biophysics beginning in June, 2001.

Research

Mechanisms of skeletal muscle plasticity in humans are the primary foci of our laboratory.  Specifically, our main objectives are to determine the etiology of muscle atrophy (sarcopenia) with aging and to determine the mechanotransduction mechanisms by which increased mechanical load induces net muscle protein synthesis and myofiber hypertrophy in both young and older adults.  We are particularly interested in the involvement of satellite cells (myogenic precursor cells) in these processes.  Local modulators of the cell cycle and myogenic signaling pathways are studied, including locally-expressed growth factors, myogenic regulatory factors, and the inhibitory protein myostatin.  We also have an ongoing interest in characterizing age-specific and gender-specific responses and adaptations to acute mechanical load and long-term resistance exercise training.  This translational research program takes advantage of cellular/subcellular/molecular studies in three wet laboratories and in vivo functional assessments in a human exercise physiology laboratory.  Together these laboratories comprise the Muscle Research Laboratory, which serves as a core facility for both the University of Alabama School of Medicine (www.uab.edu/uasom/research/resources_corelbydirector.htm) and the VA Geriatric Research, Education, and Clinical Center (www.physiology.uab.edu/BammanLab.htm).  

Selected Publications

Kim JS, JK Petrella, JM Cross and MM Bamman.  Load-mediated down-regulation of myostatin mRNA is not sufficient to promote myofiber hypertrophy in humans:  a cluster analysis.  J Appl Physiol.  Epub 02 August 2007.

Bamman MM.  Invited Editorial:  Take two NSAIDs and call on your satellite cells in the morning.  J Appl Physiol.  Epub 24 May 2007.

Huffman DM, WE Grizzle, MM Bamman, J Kim, IA Eltoum, A Elgavish, and TR Nagy.  SIRT1 is significantly elevated in mouse and human prostate cancer.  Cancer Res.  67:6612-8, 2007.

Bamman MM, JK Petrella, JS Kim, DL Mayhew, and JM Cross. Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans. J Appl Physiol. Epub 29 March 2007.

Petrella JK, SC Tuggle, JS Kim, SR Hall, and MM Bamman. Contributions of force and velocity to improved power with training in young and old. Eur J Appl Physiol. 99(4):343-51, 2007.

Brown C, C Peel, M Bamman, and R Allman. Feasibility of rehabilitation for older adults recovering from acute medical conditions. J Rehab Res Devel. 43(7):939-46, 2006.

McCarthy JP, GR Hunter, RL Weinsier, DE Larson-Meyer, MM Bamman, K Landers, and BR Newcomer. Ethnic differences in triceps surae muscle-tendon complex and walking economy. J Strength Cond Res. 20(3):511-18, 2006.

Petrella JK, JS Kim, JM Cross, DJ Kosek, and MM Bamman. Efficacy of myonuclear addition may explain differential myofiber growth among resistance trained young and older men and women. Am J Physiol Endocrinol Metab. 291(5):E937-46, 2006.

Kosek DJ, JS Kim, JK Petrella, JM Cross, and MM Bamman. Efficacy of 3 d/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young versus older adults. J Appl Physiol. 101:531-44, 2006.

Kim JS, DJ Kosek, JK Petrella, JM Cross, and MM Bamman. Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women. J Appl Physiol. 99:2149-58, 2005.

Hunter GR, MM Bamman, DE Larson, JP McCarthy, TE Blaudeau, and BR Newcomer. Inverse relationship between exercise economy and oxidative capacity in muscle: a ³¹P MRS study. Eur J Appl Physiol. 94(5-6):558-68, 2005.

Newcomer BR, B Sirikul, GR Hunter, DE Larson-Meyer, and MM Bamman.  Exercise over-stress and maximal muscle oxidative metabolism: A ³¹P MRS case report. Brit J Sport Med. 39:302-6, 2005.

Kim JS, JM Cross, and MM Bamman. Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab. 288:E1110-9, 2005.

Petrella JK, JS Kim, SC Tuggle, S Hall, and MM Bamman. Age differences in knee extension power, contractile velocity, and fatigability. J Appl Physiol. 98:211-20, 2005.

Bamman MM, RC Ragan, JS Kim, JM Cross, VJ Hill, SC Tuggle, and RM Allman. Myogenic protein expression before and after resistance loading in 26- and 64-year-old men and women. J Appl Physiol. 97:1329-37, 2004.

Durand RJ, RR Kraemer, D Hollander, JL Tyniecki, MM Bamman, LaRock, S O’Neal, and VD Castracane. Acute anabolic hormone responses to concentric and eccentric bouts of resistance exercise at the same absolute workload. Med Sci Sports Exerc. 35(6):937-43, 2003.

Bamman MM, VJ Hill, GR Adams, F Haddad, CJ Wetzstein, BA Gower, A Ahmed, and GR Hunter. Gender differences in resistance training-induced myofiber hypertrophy among older adults. J Gerontol: Biol Sci. 58A(2):108-16, 2003.

Hunter GR, BR Newcomer, RL Weinsier, DL Karapondo, DE Larson-Meyer, DR Joanisse, and MM Bamman. Age is independently related to muscle metabolic capacity in premenopausal women. J Appl Physiol. 93:70-76, 2002.

Hunter GR, DR Bryan, CJ Wetzstein, PA Zuckerman, and MM Bamman. Resistance training and intraabdominal adipose tissue in older men and women. Med Sci Sports Exerc. 34(6):1023-8, 2002.

Larson-Meyer DE, BR Newcomer, GR Hunter, DR Joanise, RL Weinsier, and MM Bamman. Relation between in-vivo and in-vitro measurements of skeletal muscle oxidative metabolism. Muscle Nerve 24:1665-76, 2001.

Landers KA, GR Hunter, CJ Wetzstein, MM Bamman, and RL Weinsier. The interrelationship between muscle mass, strength, and the ability to perform physical tasks of daily living in younger and older women. J Gerontol Biol Sci. 56A(10):443-8, 2001.

Hunter GR, CJ Wetzstein, CL McLafferty, Jr, PA Zuckerman, K Landers, and MM Bamman. High resistance versus variable resistance training in older adults. Med Sci Sports Exerc. 33(10):1759-64, 2001.

Bamman MM, JR Shipp, J Jiang, BA Gower, GR Hunter, A Goodman, CL McLafferty, and RJ Urban. Mechanical load increases muscle igf-i and androgen receptor mrna concentrations in humans. Am J Physiol Endocrinol Metab. 280:E383-90, 2001.

Hunter GR, BR Newcomer, DE Larson-Meyer, MM Bamman, and RL Weinsier.  Muscle metabolic economy is inversely related to exercise intensity and type II myofiber distribution. Muscle Nerve. 24:654-61, 2001.

Bamman MM, BR Newcomer, DE Larson-Meyer, RL Weinsier, and GR Hunter. Evaluation of the strength-size relationship in vivo using various muscle size indices. Med Sci Sports Exerc. 32(7):1307-13, 2000.

Clarke MSF, CR Vanderburg, MM Bamman, RW Caldwell, and DL Feeback. In situ localization of cholesterol in skeletal muscle using a monoclonal antibody. J Appl Physiol. 89:731-41, 2000.

Hunter GR, CJ Wetzstein, DA Fields, A Brown, and MM Bamman. Resistance training increases total energy expenditure and free living physical activity in older adults. J Appl Physiol. 89:977-84, 2000.

Bamman MM and JF Caruso. Resistance exercise for space flight: implications of training specificity. J Strength Cond Res. 14(1):45-9, 2000.

Bamman MM, MSF Clarke, RJ Talmadge, DL Feeback, and BR Stevens. Separation of myosin heavy chain isoforms in human muscle using a minigel system. Electrophoresis. 20:466-8, 1999.

Hunter GR, MM Bamman, CJ Wetzstein, K Landers, JC Hilyer, and M Weaver. Validation of fitness/physical abilities tests for evaluating the ability to do job-related tasks. Strength Cond J. 21(2):33-9, 1999.

Bamman MM, MSF Clarke, DL Feeback, RJ Talmadge, BR Stevens, SA Lieberman, and MC Greenisen. Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution. J Appl Physiol. 84(1):157-163, 1998.

Clarke MSF, MM Bamman, and DL Feeback. Decreased incidence of load-induced myofiber wounding and consequent wound-mediated FGF release during bed rest. J Appl Physiol. 85(2):593-600, 1998.

Bamman MM, GR Hunter, BR Stevens, ME Guilliams, and MC Greenisen. Resistance exercise prevents plantar flexor deconditioning during bed rest. Med Sci Sports Exerc. 29(11):1462-1468, 1997.

Bamman MM, SG Ingram, JF Caruso, and MC Greenisen. Evaluation of surface electromyography during maximal voluntary contraction. J Strength Cond Res. 11(2):68-72, 1997.

Ferrando A., K Tipton, M Bamman, and R Wolfe. Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J Appl Physiol. 82(3):807-810, 1997.

McCarthy JP, MM Bamman, J Yelle, AD LeBlanc, RM Rowe, MC Greenisen, SMC Lee, and SM Fortney. Resistance exercise training and orthostatic response. Eur J Appl Physiol. 76:32-40, 1997.

Caruso JF, JF Signorile, AC Perry, M Clark, and MM Bamman. Time course changes in contractile strength as a result of isokinetic exercise and b₂ agonist administration. J Strength Cond Res. 11(1):7-12, 1997.

Caruso JF, JF Signorile, AC Perry, B LeBlanc, R Williams, M Clark, and MM Bamman. The effects of albuterol and isokinetic exercise on the quadriceps muscle group. Med Sci Sports Exerc. 27(11): 1471-6, 1995.

Bamman MM, GR Hunter, LE Newton, RK Roney, and MA Khaled. Changes in body composition, diet, and strength of bodybuilders during the 12 weeks prior to competition. J Sports Med Phys Fitness. 33: 383-91, 1993.

Pollock ML, JE Graves, MM Bamman, SH Leggett, DM Carpenter, C Carr, J Cirulli, J Matkozich, and M Fulton. Frequency and volume of resistance training: effect on cervical extension strength. Arch Phys Med Rehabil. 74: 1080-6, 1993.

Newton LE, GR Hunter, MM Bamman, and RK Roney. Changes in psychological state and self-reported diet during various phases of training in competitive bodybuilders. J Strength Cond Res. 7(3): 153-8, 1993.