Kathleen Berecek, Ph.D.

DEPARTMENT OF PHYSIOLOGY AND BIOPHYSICS

		KATHLEEN H. BERECEK, Ph.D. Professor
	Email: berecek@uab.edu Telephone: 205.934.2411 Fax: 205.975.9028 Bldg/Room: MCLM 988

	Dr. Kathleen Berecek, Professor, received her B.S. degree from St. Xavier College in Chicago, Illinois. She received both her M.S. and Ph.D. from the University of Michigan in Ann Arbor. Dr. Berecek joined the UAB faculty as an Assistant Professor in 1981.
	Research We have two major areas of interest in my laboratory. First, we are interested in the role of the central nervous system in blood pressure regulation and the pathogenesis of hypertension. Briefly, we are exploring the role of angiotensin II and vasopressin and their interaction with the central nervous system in blood pressure control and the genesis of various forms of experimental hypertension. We are also interested in the role of the renin-angiotensin system in cardiovascular remodeling. In this area, we use animal models of experimental hypertension to determine the roles of the renin-angiotensin system and the increase arterial blood pressure on cardiovascular hypertrophy and fibrosis.
	Selected Publications Berecek, K.H. and Janson, S.L. Influence of postanesthetic suggestion on the prevention of postoperative pulmonary complications. Chest 61:240-246, 1972. Berecek, K.H. Etiology of decubitus ulcer. Nrsg. Clin. N.A. 10:157-170, 1975. Berecek, K.H. Treatment of decubitus ulcers. Nrsg. Clin. N.A. 10:171-210, 1975. Berecek, K.H. and Bohr, D.F. Bases for increased vascular reactivity in experimental Hypertension. Proc. 2nd International Symposium on Vascular Neuroeffector Mechanisms. J. Bevan, et al, eds. S. Karger, Basel, 1976, pp 199-204. Bohr, D.F. and Berecek, K.H. Relevance of vascular structural and smooth muscle sensitivity changes in hypertension. Aust. and New Zealand J Med. 6:(Suppl 2)26-34, 1976. Terris, J.M., Berecek, K.H., Cohen, E.L., Stanley, J.C., Whitehouse, W.M., Jr. and Bohr, D.F. DOCA hypertension in the pig. Clin. Sci. 51:303-305, 1976. Berecek, K.H. and Bohr, D.F. Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA) - hypertensive pig. Circ. Res., 40:(Suppl I)-146-152, 1977. Berecek, K.H. and Bohr, D.F. Whole body reactivity during the development of deoxycorticosterone acetate hypertension in the pig. Circ. Res. 42:764-770, 1978. Berecek, K.H., Rascher, W. and Gross, F. Vascular reactivity in the pathogenesis of spontaneous hypertension. Clin. Sci. 57:51-53s, 1979. Dietz, R., Haebara, H., Schomig, A., Rascher, W., Berecek, K.H., Mann, J.F.E. and Luth, M.P. The role of the kidney in the pathogenesis of spontaneous hypertension in rats. Proc. 3rd International Symposium on the Spontaneously Hypertensive Rat. Jap. Heart J. 20:(Suppl I)52-54, 1979. Ganten, D., Berecek, K., Kreye, V. and Rascher, W. Renin increases blood pressure. Lancet I: 495, 1979. Berecek, K.H. and Bohr, D.F. Evidence for a role for changes in vascular smooth sensitivity in the development deoxycorticosterone (DOCA) hypertension in the pig. Vascular Neuroeffector Mechanisms. J. Bevan, et al, eds. Raven Press: N.Y., 1980, pp. 368-370. Berecek, K.H., Schwertschlag, U., and Gross, F. Alterations in renal vascular resistance and reactivity in spontaneous hypertension of rats. Amer. J. Physiol. 238:H287-293, 1980. Berecek, K.H., Stocker, M. and Gross, F. Changes in renal vascular reactivity at various stages of deoxycorticosterone hypertension in rats. Circ. Res. 46:619-624, 1980. Berecek, K.H., Murray, R.D. and Gross, F. Significance of sodium, sympathetic innervation and central adrenergic structures on renal vascular responsiveness in DOCA-treated rats. Circ. Res. 47:675-683, 1980. Henrichs, K.J., Unger, T., Berecek, K.H. and Ganten, D. Is arterial media hypertrophy spontaneously hypertensive rats (SHR-sp) a consequence of or a cause for hypertension? Clin. Sci. 59:331s-333s, 1980. Berecek, K.H., Murray, R.D., Gross, F. and Brody, M.J. Vasopressin and vascular reactivity in development of DOCA hypertension in rats with hereditary diabetes insipidus (DI). Hypertension 4:3-12, 1982. Berecek, K.H. and Brody, M.J. Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla. Amer. J. Physiol., 242:593-601, 1982. Berecek, K.H., Barron, K.W., Webb, R.L., and Brody, M.J. Vasopressin-Central nervous system interactions in the development of DOCA hypertension. Hypertension 4(Suppl II):II-131 - II-137, 1982. Berecek, K.H. and Brody, M.J. Vasopressin and deoxycorticosterone hypertension in Brattleboro rats. In The Brattleboro Rat H.W. Sokol and H. Valtin, eds. Annals N.Y. Acad. Sci., 394:319-329, 1982. Berecek, K.H., Webb, R.L., Barron, K.W. and Brody, M.J. Vasopressin projections and central control of cardiovascular function in the Brattleboro rat. In The Brattleboro Rat H.W. Sokol and H. Valtin, eds. Annals N.Y. Acad. Sci., 394:729-734, 1982. Berecek, K.H., Barron, K.W., Webb, R.L. and Brody, M.J. Relationship between vasopressin and the anteroventral third ventricle region in deoxycorticosterone/salt hypertension (Brattleboro rat model) in the Brattleboro rat. In The Brattleboro Rat H.W. Sokol and H. Valtin, eds. Annals N.Y. Acad. Sci., 394:392-397, 1982. Berecek, K.H., Webb, R.L. and Brody, M.J. Evidence for a central role for vasopressin in cardiovascular regulation. Am. J. Physiol., 244:H852-H859, 1983. Berecek, K.H., Okuno, T., Nagahama, S, and Oparil, S. Altered vascular reactivity and baroreflex sensitivity induced by chronic central administration of captopril in the spontaneously hypertensive rat (SHR). Hypertension 5:689-700, 1983. Berecek, K.H., Olpe, H.R., Jones, R.S.G. and Hofbauer, K.G. Cardiovascular responses tomicroinjection of vasopressin into the locus coeruleus of conscious rats. Am. J. Physiol: Heart and Circulatory Physiol. 247:H675-H681, 1984. Berecek, K.H., Nagahama, S. and Oparil, S. Effect of central administration of MK-422 (the diacid form of enalapril) on the development of hypertension in the spontaneously hypertensive rat. J. Hypertension 2(Suppl 3)63-66, 1984. Berecek, K.H., Mah, S.C., Baum, R. and Hofbauer, K.G. Cardiovascular effects of intracerebroventricular injection vasopressin in unanesthetized normotensive and DOCA-salt hypertensive rats. J. Hypertension 2(Suppl 3):29-31, 1984. Berecek, K.H., Work, J., Mitchum, T.N. and Ram, S. Effects of chronic peripheral sympathectomy on plasma levels of and the pressor response to vasopressin. J. Hypertension, 3:255-230, 1985. Olpe, H.R., Berecek, K.H., Jones, R.S.G., Steinmann, M.W., Sonnenburg, C. and Hofbauer, K.G. Reduced activity of locus coeruleus neurons in SHR and DOCA-salt rats. Neuroscience Letters 61:25-29, 1985. Olpe, H.R., Berecek, K.H., Jones, R.S.G., Steinmann, M.W., Sonnenburg, C. and Hofbauer, K.G. Reduced activity of locus coeruleus neurons in hypertensive rats. J of Hypertension 3(Suppl 4):S93-S95, 1985. Berecek, K.H. and Mitchum, T.N. Role of vasopressin in the cardiovascular response to stimulation of the locus coeruleus. Endocrinology 118:1829-1834, 1986. Berecek, K.H., Shier, D.N. Alterations in renal vascular reactivity induced by chronic central adminisration of captopril in the spontaneously hypertensive rat. Clinical and Experimental Hypertension A8(7):1081-1106, 1986. Rademacher, R., Berecek, K.H. and Ploth, D.W. Effects of angiotensin inhibition and renal denervation in two-kidney one-clip hypertensive rats. Hypertension 8:1127-1134, 1986. Berecek, K.H. Role of central vasopressin in cardiovascular regulation. J. Cardiovascular Pharmacology 8(Suppl 7):S76-S80, 1986. Berecek, K.H., Olpe, H.R., Mah, S.C. and Hofbauer, K.G. Alterations in responsiveness of noradrenergic neurons of the locus coeruleus in DOCA-salt hypertensive rats. Brain Research 401:303-311, 1987. Berecek, K.H., Kirk, K., Nagahama, S. and Oparil, S. Alterations in sympathetic function in spontaneously hypertensive rats after chronic administration of captopril. American Journal of Physiology: Heart and Circulatory Physiology, 252:H796-H806, 1987. Berecek, K.H., Olpe, H.R., and Hofbauer, K.G. Enhanced responsiveness of locus coeruleus neurons in Deoxycorticosterone (DOCA)-salt hypertensive rats to microiontophoretically applied vasopressin. Hypertension, 9(Suppl III):III-110 - III-113, 1987. Berecek, K.H., Coshatt, G., Narkates, A.J., Oparil, S., Wilson, K. and Robertson, J. Captopril and the response to stress in the spontaneously hypertensive rat. Hypertension 11(Suppl I):I-144 -I-147, 1988. Wilson, K., Magargal, W. and Berecek, K.H. Long term captopril treatment: angiotensin II receptors and responses. Hypertension 11(Suppl I):I-148 - I-152, 1988. Cheng, S.W.T., Swords, B.H., Kirk, K.A. and Berecek, K.H. Effect of lifetime captopril treatment on baroreceptor function in the spontaneously hypertensive rat. Hypertension 13:63-69, 1989. Cheng, S.W.T., Wilson, K.M., Mulchahey, J.J., Stallworth, J.W. and Berecek, K.H. Vasopressin in neuronal cultures from neonatal rat brain. Hypertension, 13:902-909, 1989. Cheng, S.W.T., Kirk, K.A., Robertson, J.D. and Berecek, K.H. Brain angiotensin II and baroreflex function in spontaneously hypertensive rats. Hypertension 14:274-281, 1989. Swords, B.H., Carr D.J.J., Blalock, J.E. and Berecek, K.H. An antibody directed against a peptide encoded by RNA complementary to mRNA of vasopressin recognizes putative vasopressin receptors. Neuroendocrinology 51:487-492, 1990. Berecek, K.H. and Swords, BH. Central role for vasopressin in cardiovascular regulation and the pathogenesis of hypertension. Hypertension 16:213-224, 1990. Lee, RM, KW, Berecek, KH, Tsoporis, J, McKenzie, R and Triggle, CR. Prevention of hypertension and vascular changes in spontaneously hypertensive rats by captopril treatment. Hypertension 17:141-150, 1991. Berecek, KH, Robertson, JD, and Hernandez Thorstad, M. Central administration of a specific angiotensin II receptor antagonist on baroreflex function in spontaneously hypertensive rats. J. Hypertension 9:365-371, 1991. King SJ, Oparil S and Berecek KH. Neuronal angiotensin converting enzyme (ACE) gene expression is increased by converting enzyme inhibitors (CEI). Mol and Cell Neurosciences 2:13-20, 1991. Swords, BH, Green MM, Blalock JE, Berecek, KH, and LeBoeuf, RD. Cloning and sequencing from lambda libraries using polymerase chain reaction and direct sequencing. Netherlands Journal of Medicine 39:295-305, 1991. Swords BH, Wyss JM, and Berecek, KH. Central vasopressin receptors are upregulated by deoxycorticosterone acetate. Brain Research 559:10-16, 1991. Berecek KH, Wyss MJ, and Swords BH. Alterations in vasopressin mechanisms in captopril-treated spontaneously hypertensive rats. Clinical and Experimental Hypertension A13: (5):1019-1031, 1991. Berecek, KH, Swords, BH, Lo, S, and Stallworth, J. Effect of angiotensin converting enzyme inhibitors on brain angiotensin II binding. Journal of Hypertension 10:545-552, 1992. Wu JN and Berecek, KH Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with the angiotensin converting enzyme inhibitor captopril. Hypertension 22:139-146, 1993. Oparil S, Yang RH, Jin HG, Chen SJ, Meng QC, Berecek KH, Wyss MJ, Role of anterior hypothalamic angiotensin II in the pathogenesis of salt-sensitive hypertension in the spontaneously hypertensive rat. Am. J Med. Sci. (Suppl 1)S26-S37, 1994. Wu, JN, Edwards, D, and Berecek, KH. The effect of captopril on renal angiotensin II receptors in spontaneously hypertensive rats. Hypertension 23(Part 2):819-822, 1994. Wyss, JM, Roysommati S, King K, Kadisha I, Regan CP, and Berecek KH. Salt-induced hypertension in normotensive, spontaneously hypertensive rats. Hypertension 23(Part 2): 791-796, 1994. Wu, JN, Edwards D, Zhang L, and Berecek KH. Effects of early treatment of spontaneously hypertensive rats with an angiotensin converting enzyme inhibitor on blood pressure, baroreflex function and cardiac hypertrophy. Hypertension Research: Clinical & Exper. 17:243-251, 1994. Zhang, L, Edwards, DG, and Berecek, KH. Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in spontaneously hypertensive rats (SHR) and normotensive rats (WKY). Accepted for publication Clin. & Exp. Hypertension. Regan, CP, Anderson, PG, Bishop, SP Berecek KH. Captopril prevents vascular and fibrotic changes but not cardiac hypertrophy in aortic-banded rats. Accepted in AJP:Heart and Circulatory Physio, 1995. Berecek, KH, Zhang L, Elton TS. A quick and sensitive method for analysis of angiotension converting enzyme (ACE) messenger RNA from rat tissues. Submitted. Contributions in a Book Berecek, K.H. and Brody, M.J. Effects of stimulation of central pressor and depressor areas in SHR. Hypertensive Mechanisms: The Spontaneously Hypertensive Rat as a Model to Study Human Hypertension. Proc. 4th International Symposium on Rats with Spontaneous Hypertension and Related Studies, Rascher W., Clough D. and Ganten, D. eds. F.K. Schattauer Verlag: Stuttgart pp 394-397, 1982. Brody, M.J., Barron, K.W., Berecek, K.H., Faber, J.E. and Lappe, R.W. Neurogenic mechanisms of experimental hypertension. Hypertension J. Genest, O. Kuchel, P. Hamet and M. Cantin eds. McGraw-Hill:N.Y.; 1983, pp 117-140. Berecek, K.H. and Hofbauer, K.G. Neuropeptides as modulators of blood pressure. In Progress in Hypertension (Vol. I) Neurotransmitters as Modulators of Blood Pressure. H. Saito, H. Parvez, S. Parvez and T. Nagatsu, eds. VNU Int. Science Press, Utrecht, Holland, 1988, pp 231-260. Swords, BH, Wyss JM, and Berecek, KH. Vasopressin and vasopressin receptors are enhanced in the central nervous system in deoxycorticosterone NaCl Hypertension. In: Vasopressin, Jard S, Jamison R, eds. Paris: Colloque Inserm/John Libbey Eurotext Ltd.; 1991, pp 3-11. Berecek, KH, King, SJ, Wu, J-N, Angiotensin Converting Enzyme and Converting Enzyme Inhibitors, in Cellular and Molecular Biology of the Renin-Angiotensin System, CRC Press, Inc., Boca Raton, Florida, 1993, pp 183-220. Berecek KH, Role of vasopressin in central cardiovascular regulation in Central Neural Mechanisms in Cardiovascular Regulation vol 2 G Kunos and J Ciriello eds Birkhauser: Boston, 1992 pp. 1-34. Berecek, KH and Wyss, JM. Catecholamine receptors and actions. in Hypertension Primer, J. Izzo and H. Black editors, American Heart Association 1993. Oparil S, Chen, Y-F, Berecek, KH, Calhoun, DA, and Wyss, JM. The role of the central nerous system in hypertension. In Hypertension: Pathophysiology, Diagnosis and Management. JH Laragh, BM Brenner, eds, Raven Press: NY, 1995, pp. 713--740. Berecek KH and Zhang, L. Biochemistry and cell biology of angiotensin-converting enzyme and converting enzyme inhibitors. In Tissue Renin-Angiotensin Systems. AK Mukhopadhyay and MK Raizada, Plenum Press, NY 1995, pp. 141-168. Abstracts Berecek, K.H. and Bohr, D.F. Vascular reactivity to norepinephrine in renal hypertensive rats. Fed Proc 34:382, 1975. Berecek, K.H. and Bohr, D.F. Vascular reactivity in renal and DOCA hypertensive rats. The Physiologist 18:139, 1975. Bohr, D.F. and Berecek, K.H. Bases for increased vascular reactivity in experimental hypertension. Blood Vessels 12:332-333, 1975. Berecek, K.H. and Bohr, D.F. Vascular reactivity in the DOCA hypertensive pig. The Physiologist 19:124, 1976. Terris, J.M., Cohen, E.L., Berecek, K.H., Stanley, J.C., White, D.C. and Bohr, D.F. DOCA hypertension in the pig. Fed. Proc. 35:770, 1976. Berecek, K.H. and Bohr, D.F. Systemic vascular reactivity in the DOCA hypertensive pig. The Physiologist 20:8, 1977. Berecek, K.H. and Bohr, D.F. Functional changes in vascular smooth muscle in the DOCA hypertensive pig. Abstracts, 5th Scientific Meeting of the International Society of Hypertension, 1978. Berecek, K.H., Rascher, W. and Gross, R. Changes in vascular reactivity in perfused hindlimb and kidney of young stroke-prone spontaneously hypertensive rats (spSHR). Blood Vessels 16:208-209, 1979. Berecek, K.H., Murray, R.D. and Gross, R. Increased vascular reactivity as a primary mechanism in spontaneous and deoxycorticosterone hypertension in rats. The Physiologist 22:9, 1979. Berecek, K.H., Shaffer, R.A. and Brody, M.J. Mechanisms of the hindlimb vasodilator response to activation of the anteroventral third ventricle (AV3V) region. Fed Proc 39:3643, 1980. Berecek, K.H., Murray, R.D., Brody, M.J. and Gross, R. Vasopressin (VP) and vascular reactivity in the development of deoxycorticosterone hypertension in rats with hereditary diabetes insipidus (DI). Circulation, 62:III-24, 1980. Berecek, K.H., Shaffer, R.A., and Brody, M.J. Circulating epinephrine (Epi) is the source for the sympathetic transmitter mediating active beta-adrenergic vasodilation. Circulation, 62:III-221, 1980. Berecek, K.H., Barron, K.W., Webb, R.L. and Brody, M.J. Vasopressin (VP) and the anteroventral third ventricle (AV3V) region in DOCA hypertension. Fed Proc 40:390, 1981. Berecek, K.H. and Brody, M.J. Vasopressin projections and central control of cardiovascular function. International Symposium on the Brattleboro Rat, 1982. Berecek, K.H. and Brody, M.J. Vasopressin and deoxycorticosterone hypertension in rats with hereditary diabetes insipidus. International Symposium on the Brattleboro Rat, 1982. Berecek, K.H., Allen, D. and Brody, M.J. Cardiovascular effects of paraventricular nucleus stimulation in normal and DOCA hypertensive rats (DHR). Fed Proc 41:5772, 1982. Berecek, K.H., Webb, R.L., Allen, D. and Brody, M.J. Central vasopressin (VP) projections and cardiovascular (CV) function. American Heart Association, 1982. Berecek, K.H., Nagahama, S. and Oparil, S. Altered vascular reactivity (VR) and baroreflex sensitivity induced by central administration of captopril (CP) in the spontaneously hypertensive rat (SHR). Clin Res 30:848A, 1982. Berecek, K.H., Winternitz, S.R. and Oparil S. Enhanced sympathetic vasoconstrictor tone during high sodium (Na+) intake in the spontaneously hypertensive rat (SHR). Fed Proc, 42:1261, 1983. Berecek, K.H., Winternitz, S.R., Wyss, J.M. and Oparil S. Exaggerated responsiveness to central sympathetic and alpha adrenergic stimulation in spontaneously hypertensive rats receiving high sodium intake. Clin Res 31:487A, 1983. Berecek, K.H., Nagahama S., Mitchum T.N. and Oparil S. Attenuation of hypertension in the spontaneously hypertensive rat (SHR) by chronic central administration of MK-422. Clin. Res. 31:843A, 1983. Berecek, K.H., Nagahama, S., Mitchum, T.N. and Oparil, S. Attenuated responsiveness to sympathetic stimulation in spontaneously hypertensive rats (SHR) after chronic central administration of captopril. Circulation 68: Supp III, 385, 1983. Berecek, K.H., Olpe H., Jones, R.E. and Hofbauer, K.G. Cardiovascular (CV) responses to microinjection of vasopressin (AVP) into the locus coeruleus (LC) of the conscious rat. Fed Proc 43:1068, 1984. Work, J., Berecek, K.H., Mitchum, T. and Ram, S. Effect of chronic sympathectomy (SX) on plasma levels of vasopressin (PAVP) and pressor sensitivity to vasopressin (VP) in rats. Fed Proc 43:896, 1984. Berecek, K.H., Olpe, H., Jones, R.S., Hofbauer, K.G. Cardiovascular (CV) effects of injection of vasopressin (AVP) into the locus coeruleus (LC) of the conscious rat. Proceedings of the Symposium on Neuropeptides and Blood Pressure Control Heidelberg, West Germany pg. 41, 1984. Berecek, K.H., Mah, S.C., Baum, P. and Hofbauer, K.G. Cardiovascular (CV) effects of intracerebro-ventricular (ICV) injection of vasopressin (AVP) in unanesthetized normotensive and hypertensive rats. Proceeding 10th Meeting of the International Society of Hypertension, June, 1984. Berecek, K.H., Okuno, T., Nagahama, S. and Oparil, S. Effect of central administration of converting enzyme inhibitors (CEI) on the development of hypertension in the spontaneously hypertensive rat (SHR). Proceedings of the 10th Meeting of the International Society of Hypertension, June, 1984. Berecek, K.H. and Mitchum, T.N. Evidence for participation of vasopressin in central neural regulation of the cardiovascular system. Clin. Res. 32:826A, 1984. Shier, D.N., Robertson, J., Benn, K. and Berecek, K.H. Evidence that sodium (Na+) retention closely precedes the development of hypertension in the deoxycorticosterone (DOCA)/Salt treated rat. Clin. Res. 32:845A, 1984. Berecek, K.H. and Robertson, J. The effects of electrical stimulation and lesion of the locus coeruleus (LC) in DOCA/salt hypertensive rats (DHR). Fed. Proc. 44:6686, 1985. Berecek, K.H. Locus coeruleus and central effects of vasopressin in DOCA/salt hypertensive rats. Hypertension 7:849, 1985. Shier, D.N. and Berecek, K.H. Subpressor vasopressin (VP) enhancement of norepinephrine (NE) dose response is greater in DOCA hypertension. Circulation 72:III-420, 1985. Berecek, K.H., Olpe, H-R and Hofbauer, K.G. Enhanced responsiveness of noradrenergic (NA) neurons of the locus coeruleus (LC) of DOCA-salt hypertensive rats to microiontophoretic application of vasopressin (AVP). Fed. Proc. 45:392, 1986. Shier, David N., Rousseau, Ryllis and Berecek, Kathleen H. Subpressor vasopressin infusion potentiates the renovascular response to norepinephrine in DOCA-salt hypertensive rats. Fed. Proc. 45:895, 1986. Berecek, K.H., Olpe, H.R. and Hofbauer, K.G. Alterations in responsiveness of noradrenergic (NA) neurons of the locus coeruleus (LC) in DOCA/salt hypertensive rats (DHR). Hypertension, 8:829, 1986. Wilson, K.M., Robertson, J. and Berecek, K.H. Captopril and central angiotensin II (ANG II) receptors in the spontaneously hypertensive rat (SHR). Fed. Proc. 40:968, 1987. Berecek, K.H., Wilson, K.M., Magargal, W.W. Effect of chronic captopril (CP) treatment on peripheral vascular reactivity and angiotensin II (AII) receptor binding in SHR. Fed. Proc. 40:802, 1987. Coshatt, G., Narkates, A., Robertson, J., Oparil, S. and Berecek, K.H. Brain Renin-Angiotensin (AII) and the response to stress in the spontaneously hypertensive rat (SHR). Fed. Proc. 40:1239, 1987. Berecek, K.H., Coshatt, G., Narkates, A.J., Oparil, S. and Robertson, J. Brain renin-angiotensin system and the response to stress in the spontaneously hypertensive rat. Hypertension 9:527, 1987. Berecek, K.H., Wilson, K.M., Magargal, W. Effect of lifetime captopril treatment on drinking, peripheral vascular reactivity and angiotensin II (AII) receptor binding in SHR. Hypertension 9:527, 1987. Cheng, S., Swords, B., Kirk, K. and Berecek, K. Effects of lifetime captopril treatment on baroreceptor function in the spontaneously hypertensive rat (SHR). The FASEB JOURNAL 2: A717, 1988. Wilson, K., Cheng, S. and Berecek, K. Vasopressin (VP) in neuronal cultures from neonatal rat brain. The FASEB JOURNAL 2:A1153, 1988. Cheng, S.W.T., Wilson, K.M. and Berecek, K.H. Measurements of vasopressin (VP) in primary neuronal cultures from rat brain. Hypertension 12:356, 1988. Berecek, K.H. and Cheng, S.W.T. Enhanced baroreflex sensitivity in captopril (CAP) treated SHR is due to an inhibition of brain angiotensin II (AII) mechanisms. Hypertension 12:347, 1988. Berecek, K.H. and Cheng, S.W.T. Enhanced baroreflex sensitivity in captopril (CAP) treated SHR is due to an inhibition of brain angiotensin II (AII) mechanisms. Neuroscience Abst. 14:915, 1988. Swords, B.H. and Berecek, K.H. Enhanced 3H-vasopressin (3H-AVP) binding in deoxycorticosterone acetate (DOCA)-treated primary neuronal cultures. The FASEB Journal 3:A-725, 1989. Berecek, K.H., Wyss, J.M., Swords, B.H. and Stallworth, J. Vasopressin (AVP) mechanisms in captopril (CAP) treated spontaneously hypertensive rats (SHR). The FASEB Journal 3:A-585, 1989. Chen, FP, Cheng, SWT, Robertson, J, and Berecek, KH. L-glutamate (GLU) stimulation of the locus coeruleus (LC) increases arterial pressure (AP) in conscious rats. The FASEB J. 4:A1193, 1990. Berecek, KH, Swords, BH, and Stallworth, J. Effects of angiotensin converting enzyme inhibitors (CEI) on brain angiotensin II (AII) binding. The FASEB J. 4:A868, 1990. Swords, BH and Berecek, KH. Effects of deoxycorticosterone acetate (DOCA) on neuronal vasopressin (AVP) binding. The FASEB J. 4:A1067, 1990. King SJ, Robertson J, Stallworth J and Berecek KH. The effect of angiotensin-converting enzyme (ACE) inhibitors on ACE mRNA in neuronal cells. The FASEB J. 4:A992, 1990. Lee, RMKW, Berecek, KH, McKenzie R, Tsoporis J, Triggle CR. Prevention of hypertension and cardiovascular changes by chronic captopril treatment in the spontaneously hypertensive rat. J Hypertension 8(Suppl 3):S5, 1990. Swords, BH, LeBoeuf, RD, Berecek, KH, and Blalock, JE. Application of the molecular recognition theory to the cloning and sequencing of the arginine vasopressin (AVP) receptor. FASEB J. 4:A2142, 1990. Berecek, KH, Swords, BH. Effects of angiotensin converting enzyme inhibitors (CEI) on brain angiotensin II (AII) binding. Hypertension 16(3):320, 1990. Berecek, KH, Chen, YF, Oparil S. Atrial natriuretic peptide (ANP) in neuronal cells from normotensive (WKY), spontaneously hypertensive (SHR) and captopril (CAP) treated rats. FASEB J, 5:A1068, 1991. King, SJ, Berecek, KH, Oparil S. Angiotensin converting enzyme (ACE) inhibitors enhance ACE gene expression. Am J Hypertension, 4:81A, 1991. Wu JN, Zhang L, Moellering D, Francis S, Tjepkes D, King S, Berecek KH. Early Treatment of spontaneously hypertensive rats (SHR) with the angiotensin (AII) converting enzyme inhibitor captopril (CAP) prevents the subsequent development of hypertension and decreases central AII responses. FASEB J, 6(4):A945, 1992. Wu JN, Zhang L, King S, Edwards D, Berecek KH. Early treatment with captopril (CAP) permanently alters hypertension in spontaneously hypertensive rats (SHR). Hypertension, 20: 401,1992 King SJ, Berecek KH, Oparil S, Rydzewski B, and Raizada, M. Angiotensin-converting enzyme (ACE) gene expression is decreased after exposure to angiotensin II (Ang I) in vitro. 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Losartan prevents arterial medial wall thickening and the increase in minimal coronary resistance but not hypertrophy in aortic banded rats. FASEB J. 9:A334, 1995.